Drugs of Abuse Differentially Alter the Neuronal Excitability of Prefrontal Layer V Pyramidal Cell Subtypes
The medial prefrontal cortex (mPFC) plays an important role in regulating executive functions including reward seeking, task flexibility, and compulsivity.Studies in humans have demonstrated that drugs of abuse, including heroin, copyright, methamphetamine, and alcohol, alter prefrontal function resulting in the consequential loss of inhibitory con